Origin & tradition
Not traditional: urolithin A is produced by gut bacteria from ellagitannins (pomegranate, walnuts) and only some people make it.
Western tradition · Mitophagy activator
Urolithin A 尿石素 A
A gut-derived metabolite that triggers mitophagy — with human trials on muscle and mitochondrial function.
32ClinicalTrials.gov matched
28PubMed RCT records
7Meta-analysis records
12+PubMed records
Urolithin AKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Urolithin A (gut-microbial metabolite).
Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Mitophagy markers / mitochondrial function | Increases | Moderate | B |
| Muscle endurance (handgrip, leg strength) | Increases | Moderate | B |
| VO2 max | Increases | Minor | C |
| Inflammation markers | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Urolithin A is typically used
- Typical dose
- 500–1,000 mg/day
- Form
- capsule (Mitopure by Timeline is the clinical-grade form)
- Timing
- any time, with or without food
Urolithin A is produced by gut bacteria from ellagitannins (pomegranate, walnuts, raspberries). ~40% of people lack the gut bacteria to produce it — direct supplementation bypasses this. Most human data comes from Timeline's Mitopure trials.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
76Evidence confidence
Human RCT evidence28 randomized controlled trials · 7 meta-analyses / systematic reviews
Human RCTs (muscle, mitochondria); clear mechanism
Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.
32registered clinical trials reference this intervention
3selected from 12+ PubMed papers (longevity / aging angle)
- Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Key active: Urolithin A (gut-microbial metabolite).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Urolithin A appears in
Compare the evidence
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Compare the evidence
How Urolithin A stacks up
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