Origin & tradition
Not traditional: urolithin A is produced by gut bacteria from ellagitannins (pomegranate, walnuts) and only some people make it.
Western tradition · Mitophagy activator
Urolithin A 尿石素 A
A gut-derived metabolite that triggers mitophagy — with human trials on muscle and mitochondrial function.
Why longevity buyers care
Key active: Urolithin A (gut-microbial metabolite).
Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.
Evidence summary
What the research actually says
76Evidence confidence
Human RCT evidence25 randomized controlled trials · 5 meta-analyses / systematic reviews
Human RCTs (muscle, mitochondria); clear mechanism
Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.
31registered clinical trials reference this intervention
3selected from 12+ PubMed papers (longevity / aging angle)
- Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Key active: Urolithin A (gut-microbial metabolite).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Urolithin A stacks up
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