Origin & tradition
Not a supplement: rapamycin is an FDA-approved immunosuppressant/mTOR inhibitor now studied off-label for aging.
Western tradition · mTOR inhibitor · prescription
Rapamycin (Sirolimus) 雷帕霉素
The single most reproducible lifespan-extending molecule in animals — a prescription drug under off-label longevity study.
Why longevity buyers care
Key active: Rapamycin / sirolimus (mTOR inhibitor).
mTOR inhibition extends lifespan across yeast, worms, flies, and mice more reproducibly than any other intervention; human longevity use is off-label and dosing/safety (the PEARL trial and others) is the open question.
Evidence summary
What the research actually says
75Evidence confidence
Extensive human-trial evidence2,105 randomized controlled trials · 635 meta-analyses / systematic reviews
Gold-standard animal lifespan data; human longevity off-label, early
mTOR inhibition extends lifespan across yeast, worms, flies, and mice more reproducibly than any other intervention; human longevity use is off-label and dosing/safety (the PEARL trial and others) is the open question.
2,358registered clinical trials reference this intervention
3selected from 369+ PubMed papers (longevity / aging angle)
Key active: Rapamycin / sirolimus (mTOR inhibitor).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-06. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Rapamycin (Sirolimus) stacks up
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