Origin & tradition
Not a supplement: rapamycin is an FDA-approved immunosuppressant/mTOR inhibitor now studied off-label for aging.
Western tradition · mTOR inhibitor · prescription
Rapamycin (Sirolimus) 雷帕霉素
The single most reproducible lifespan-extending molecule in animals — a prescription drug under off-label longevity study.
2,368ClinicalTrials.gov matched
2114PubMed RCT records
646Meta-analysis records
372+PubMed records
Rapamycin / sirolimusKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Rapamycin / sirolimus (mTOR inhibitor).
mTOR inhibition extends lifespan across yeast, worms, flies, and mice more reproducibly than any other intervention; human longevity use is off-label and dosing/safety (the PEARL trial and others) is the open question.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| mTORC1 inhibition (autophagy induction) | Increases | Strong | A |
| Lifespan (mouse models) — Most replicated mammalian lifespan result; 9–14% increase at mid-life dosing | Increases | Strong | A |
| Immune function / infection risk — Dose-dependent; lower intermittent doses may have less immunosuppression | Decreases | Moderate | B |
| Insulin sensitivity — Risk at higher doses; intermittent low doses may not impair | Decreases | Minor | B |
| Cardiac function (older adults) | Increases | Moderate | B |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Rapamycin (Sirolimus) is typically used
Prescription medication — requires a licensed prescriber. Not a supplement.
- Typical dose
- 1–6 mg/week (intermittent, off-label longevity use)
- Form
- tablet (prescription only — sirolimus)
- Timing
- once weekly, same day each week
PRESCRIPTION ONLY. Not a supplement. Used in longevity medicine off-label; prescribed protocols vary (1mg–10mg/week). Clinical use at daily doses (up to 40mg) for organ transplant rejection. Longevity-specific dosing based on emerging data from the ITP and physician protocols (Attia, Green).
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
75Evidence confidence
Extensive human-trial evidence2,114 randomized controlled trials · 646 meta-analyses / systematic reviews
Gold-standard animal lifespan data; human longevity off-label, early
mTOR inhibition extends lifespan across yeast, worms, flies, and mice more reproducibly than any other intervention; human longevity use is off-label and dosing/safety (the PEARL trial and others) is the open question.
2,368registered clinical trials reference this intervention
3selected from 372+ PubMed papers (longevity / aging angle)
Key active: Rapamycin / sirolimus (mTOR inhibitor).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Rapamycin (Sirolimus) appears in
Compare the evidence
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How Rapamycin (Sirolimus) stacks up
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