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Evidence comparison

Urolithin A vs Coenzyme Q10

How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.

Western · Mitophagy activator

Urolithin A

尿石素 A

76Confidence

Human RCT evidence

RCTs
25
Meta
5
Trials
31

Key active: Urolithin A (gut-microbial metabolite)

Human RCTs (muscle, mitochondria); clear mechanism

Urolithin A induces mitophagy (recycling of damaged mitochondria); randomized human trials report improved muscle endurance and mitochondrial gene expression in older adults.

Full Urolithin A evidence →

Western · Mitochondrial cofactor

Coenzyme Q10

辅酶 Q10

76Confidence

Extensive human-trial evidence

RCTs
523
Meta
198
Trials
251

Key active: Coenzyme Q10 (ubiquinone / ubiquinol)

Human RCTs (cardiovascular, statin myopathy); mitochondrial rationale

CoQ10 is essential to the mitochondrial respiratory chain and acts as a lipid-phase antioxidant; the KiSel-10 trial linked CoQ10 plus selenium to reduced cardiovascular mortality in older adults.

Full Coenzyme Q10 evidence →

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Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.