Origin & tradition
Not traditional: fisetin occurs in strawberries and other plants; its senolytic profile emerged from aging research.
Western tradition · Senolytic · flavonoid
Fisetin 漆黄素
A plant flavonoid and leading senolytic candidate — clearing “zombie” senescent cells in animal models.
36ClinicalTrials.gov matched
7PubMed RCT records
12Meta-analysis records
23+PubMed records
FisetinKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Fisetin (flavonoid senolytic).
Fisetin selectively clears senescent cells and extended lifespan and healthspan in aged mice; human senolytic trials are early-stage, making this promising-but-unproven.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Senescent cell markers (p21, p16) — Early human data; strong animal evidence | Decreases | Minor | C |
| Inflammation (IL-6, TNF-α) | Decreases | Minor | C |
| Cognitive function (animal models) | Increases | Moderate | D |
| Oxidative stress markers | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Fisetin is typically used
- Typical dose
- 100–200 mg/day (daily) or 500–1,500 mg × 2 days/month (senolytic protocol)
- Form
- capsule
- Timing
- with a fat-containing meal
Most human evidence uses high-dose intermittent protocols for senolytic effect. Daily low-dose is more common for antioxidant/neuroprotective purposes. Bioavailability is low — liposomal forms are under study.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
66Evidence confidence
Early / limited human trials7 randomized controlled trials · 12 meta-analyses / systematic reviews
Strong animal senolytic data; human trials early
Fisetin selectively clears senescent cells and extended lifespan and healthspan in aged mice; human senolytic trials are early-stage, making this promising-but-unproven.
36registered clinical trials reference this intervention
3selected from 23+ PubMed papers (longevity / aging angle)
Key active: Fisetin (flavonoid senolytic).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Fisetin appears in
Compare the evidence
Related ingredients
Quercetin槲皮素
70A widespread dietary flavonoid, studied as a senolytic partner (with dasatinib) and anti-inflammatory.
Urolithin A尿石素 A
76A gut-derived metabolite that triggers mitophagy — with human trials on muscle and mitochondrial function.
Rapamycin (Sirolimus)雷帕霉素
75The single most reproducible lifespan-extending molecule in animals — a prescription drug under off-label longevity study.
Compare the evidence
How Fisetin stacks up
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