How it works
Senescent cells — cells that stop dividing but refuse to die — accumulate with age and secrete a toxic inflammatory cocktail (SASP) that damages neighboring tissue. Senolytics selectively clear them, extending healthspan in animals and entering early human trials.
Evidence overview
A curated set of compounds studied for their ability to selectively eliminate senescent cells. Evidence ranges from strong animal data (fisetin, quercetin) to early human Phase 1/2 trials, with rapamycin also suppressing mTOR-driven senescence.
A plant flavonoid and leading senolytic candidate — clearing “zombie” senescent cells in animal models.
A widespread dietary flavonoid, studied as a senolytic partner (with dasatinib) and anti-inflammatory.
A gut-derived metabolite that triggers mitophagy — with human trials on muscle and mitochondrial function.
The single most reproducible lifespan-extending molecule in animals — a prescription drug under off-label longevity study.
Sourcing & due diligence
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