Origin & tradition
Resveratrol bridges East and West: abundant in red grapes and red wine, it is also the key active in Hu Zhang (虎杖, Japanese knotweed), a herb used in traditional Chinese medicine.
Both tradition · Polyphenol · sirtuin activator
Resveratrol 白藜芦醇
The grape-and-knotweed polyphenol that launched the sirtuin era of longevity research.
Why longevity buyers care
Key active: Resveratrol (stilbene polyphenol).
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
Evidence summary
What the research actually says
74Evidence confidence
Large model-organism + human literature; sirtuin / CR-mimetic mechanism; human outcomes mixed
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
230registered clinical trials reference this intervention
2selected from 12+ PubMed papers (longevity / aging angle)
Key active: Resveratrol (stilbene polyphenol).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-05. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Compare the evidence
How Resveratrol stacks up
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