Origin & tradition
Resveratrol bridges East and West: abundant in red grapes and red wine, it is also the key active in Hu Zhang (虎杖, Japanese knotweed), a herb used in traditional Chinese medicine.
Both tradition · Polyphenol · sirtuin activator
Resveratrol 白藜芦醇
The grape-and-knotweed polyphenol that launched the sirtuin era of longevity research.
232ClinicalTrials.gov matched
275PubMed RCT records
272Meta-analysis records
13+PubMed records
ResveratrolKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Resveratrol (stilbene polyphenol).
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| SIRT1 pathway activity | Increases | Moderate | B |
| Fasting blood glucose | Decreases | Minor | B |
| Systolic blood pressure | Decreases | Minor | B |
| Inflammation (CRP, IL-6) | Decreases | Minor | B |
| Lipid oxidation markers | Decreases | Minor | C |
| Cognitive function | Increases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Resveratrol is typically used
- Typical dose
- 100–500 mg/day
- Form
- capsule (trans-resveratrol)
- Timing
- with a fat-containing meal for better absorption
Bioavailability is inherently low (~1%). Pterostilbene is a more bioavailable structural analogue. Micronized or liposomal forms may help.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
74Evidence confidence
Extensive human-trial evidence275 randomized controlled trials · 272 meta-analyses / systematic reviews
Large model-organism + human literature; sirtuin / CR-mimetic mechanism; human outcomes mixed
Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.
232registered clinical trials reference this intervention
2selected from 13+ PubMed papers (longevity / aging angle)
Key active: Resveratrol (stilbene polyphenol).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Resveratrol appears in
Compare the evidence
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Compare the evidence
How Resveratrol stacks up
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