Collections · Evidence-graded
NAD+ Boosters
Restore the cellular energy currency that declines with age
How it works
NAD+ (nicotinamide adenine dinucleotide) is a co-factor in over 500 enzymatic reactions including sirtuin activation, PARP DNA repair, and mitochondrial energy production. Cellular NAD+ drops ~50% between age 40 and 60, driving multiple aging hallmarks. Multiple precursors and synergistic compounds can restore it via different routes.
Evidence overview
The compounds most studied for raising cellular NAD+ levels: direct precursors (NMN, NR, nicotinamide) that feed the biosynthesis pathway, and synergistic agents (apigenin inhibiting NAD+-consuming CD38, TMG sustaining the methylation cycle, resveratrol/pterostilbene activating sirtuins).
The headline NAD+ booster of the longevity world — human trials show it raises blood NAD+ and may support physical function.
The leading NMN alternative — a direct NAD+ precursor with multiple RCTs confirming it safely raises NAD+ levels in humans.
The simplest and cheapest NAD+ precursor — with extensive human trial data in skin aging and DNA repair.
A flavone from parsley and chamomile that inhibits CD38 (NADase) — preserving NAD+ through a complementary mechanism to NMN or NR.
A more bioavailable cousin of resveratrol, often paired with NAD precursors in longevity formulas.
A potent methyl donor that clears homocysteine, sustains the SAM methylation cycle, and is increasingly paired with NMN in longevity stacks.
The grape-and-knotweed polyphenol that launched the sirtuin era of longevity research.
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