Origin & tradition
Not traditional as an isolate, though apigenin is abundant in chamomile tea and parsley, both used medicinally for centuries.
Western tradition · Flavonoid
Apigenin 芹菜素
A flavone from parsley and chamomile that inhibits CD38 (NADase) — preserving NAD+ through a complementary mechanism to NMN or NR.
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Why longevity buyers care
Key active: Apigenin (flavone — CD38 inhibitor & SIRT1 modulator).
Apigenin inhibits CD38, an ectoenzyme that consumes ~60% of cellular NAD+. This creates mechanistic synergy with NMN/NR: more precursor + less degradation. Apigenin also modulates SIRT1, CK2, and NF-κB. Most longevity evidence is preclinical; anti-cancer and anti-inflammatory human trials are ongoing.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| CD38 inhibition / NAD+ preservation — Mechanism well-characterized; human outcome data limited | Increases | Minor | C |
| Anxiety / sleep (chamomile) | Decreases | Minor | C |
| Inflammation markers | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Apigenin is typically used
- Typical dose
- 50–200 mg/day
- Form
- capsule
- Timing
- any time, with meals for better absorption
Apigenin inhibits CD38, an enzyme that consumes NAD+. Chamomile tea is a rich dietary source (~3–5mg per cup). Used by some longevity practitioners to complement NMN/NR by reducing NAD+ degradation. Human trial data is limited.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
70Evidence confidence
Human RCT evidence15 randomized controlled trials · 34 meta-analyses / systematic reviews
Strong preclinical (CD38/NAD+/SIRT1); human cancer/anti-inflammatory trials
Apigenin inhibits CD38, an ectoenzyme that consumes ~60% of cellular NAD+. This creates mechanistic synergy with NMN/NR: more precursor + less degradation. Apigenin also modulates SIRT1, CK2, and NF-κB. Most longevity evidence is preclinical; anti-cancer and anti-inflammatory human trials are ongoing.
17registered clinical trials reference this intervention
0selected peer-reviewed papers (longevity / aging angle)
Key active: Apigenin (flavone — CD38 inhibitor & SIRT1 modulator) — a multi-compound botanical extract, so activity is not reducible to a single molecule.
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-06-12. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Apigenin appears in
Compare the evidence
Related ingredients
NMN (Nicotinamide Mononucleotide)β-烟酰胺单核苷酸
79The headline NAD+ booster of the longevity world — human trials show it raises blood NAD+ and may support physical function.
Nicotinamide Riboside (NR)
79The leading NMN alternative — a direct NAD+ precursor with multiple RCTs confirming it safely raises NAD+ levels in humans.
Nicotinamide (Niacinamide / B3)
76The simplest and cheapest NAD+ precursor — with extensive human trial data in skin aging and DNA repair.
Pterostilbene紫檀芪
68A more bioavailable cousin of resveratrol, often paired with NAD precursors in longevity formulas.
Compare the evidence
How Apigenin stacks up
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