Origin & tradition
NMN is not a traditional remedy but a modern molecule at the center of the NAD+ longevity field studied at Harvard and Washington University. NAD+, the coenzyme it feeds, declines with age.
Western tradition · NAD+ precursor · Longevity supplement
NMN (Nicotinamide Mononucleotide) β-烟酰胺单核苷酸
The headline NAD+ booster of the longevity world — human trials show it raises blood NAD+ and may support physical function.
32ClinicalTrials.gov matched
19PubMed RCT records
11Meta-analysis records
31+PubMed records
Nicotinamide mononucleotideKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Nicotinamide mononucleotide (NAD+ precursor).
NMN is a direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and sirtuin activity and declines with age. A 2022 randomized, placebo-controlled trial in healthy middle-aged adults found dose-dependent increases in blood NAD+ and improved six-minute walking distance.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| NAD+ blood levels | Increases | Strong | B |
| Physical endurance / VO2 max | Increases | Minor | C |
| Insulin sensitivity | Increases | Minor | C |
| DNA repair markers | Increases | Minor | C |
| Skin hydration & elasticity | Increases | Minor | C |
| Blood pressure | No change | Negligible | D |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How NMN (Nicotinamide Mononucleotide) is typically used
- Typical dose
- 250–500 mg/day
- Form
- capsule or sublingual powder
- Timing
- morning, with or without food
Higher doses up to 1,500 mg/day studied in some trials; start low. Sublingual may improve absorption.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
79Evidence confidence
Human RCT evidence19 randomized controlled trials · 11 meta-analyses / systematic reviews
Human RCTs on NAD+ levels & physical function; long-term longevity outcomes still open
NMN is a direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and sirtuin activity and declines with age. A 2022 randomized, placebo-controlled trial in healthy middle-aged adults found dose-dependent increases in blood NAD+ and improved six-minute walking distance.
32registered clinical trials reference this intervention
2selected from 31+ PubMed papers (longevity / aging angle)
Key active: Nicotinamide mononucleotide (NAD+ precursor).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
NMN (Nicotinamide Mononucleotide) appears in
Compare the evidence
Related ingredients
Nicotinamide Riboside (NR)
79The leading NMN alternative — a direct NAD+ precursor with multiple RCTs confirming it safely raises NAD+ levels in humans.
Nicotinamide (Niacinamide / B3)
76The simplest and cheapest NAD+ precursor — with extensive human trial data in skin aging and DNA repair.
Apigenin芹菜素
70A flavone from parsley and chamomile that inhibits CD38 (NADase) — preserving NAD+ through a complementary mechanism to NMN or NR.
Pterostilbene紫檀芪
68A more bioavailable cousin of resveratrol, often paired with NAD precursors in longevity formulas.
Compare the evidence
How NMN (Nicotinamide Mononucleotide) stacks up
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