Evidence comparison

NMN (Nicotinamide Mononucleotide) vs Resveratrol

How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.

Western · NAD+ precursor · Longevity supplement

NMN (Nicotinamide Mononucleotide)

β-烟酰胺单核苷酸

79Confidence

Human RCT evidence

RCTs: 17
Meta: 10
Trials: 31

Key active: Nicotinamide mononucleotide (NAD+ precursor)

Human RCTs on NAD+ levels & physical function; long-term longevity outcomes still open

NMN is a direct precursor to NAD+, the coenzyme that fuels mitochondrial energy and sirtuin activity and declines with age. A 2022 randomized, placebo-controlled trial in healthy middle-aged adults found dose-dependent increases in blood NAD+ and improved six-minute walking distance.

Full NMN (Nicotinamide Mononucleotide) evidence →

Both · Polyphenol · sirtuin activator

Resveratrol

白藜芦醇

74Confidence

Extensive human-trial evidence

RCTs: 270
Meta: 262
Trials: 230

Key active: Resveratrol (stilbene polyphenol)

Large model-organism + human literature; sirtuin / CR-mimetic mechanism; human outcomes mixed

Resveratrol is studied as a SIRT1 activator and calorie-restriction mimetic acting on AMPK, NRF2 and telomere/senescence pathways. Reviews report improved healthspan and lifespan across model organisms; human results are more mixed and formulation-dependent.

Full Resveratrol evidence →

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Commission research

Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.