Longevity Atlas

Western tradition · Polyphenol

Pterostilbene 紫檀芪

A more bioavailable cousin of resveratrol, often paired with NAD precursors in longevity formulas.

See the evidenceGenerate Intel File →
20ClinicalTrials.gov matched
8PubMed RCT records
2Meta-analysis records
10+PubMed records
PterostilbeneKey active compound

Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.

Origin & tradition

Not traditional as an isolate; pterostilbene is found in blueberries and is studied as a resveratrol analog.

Why longevity buyers care

Key active: Pterostilbene (methylated stilbene).

Pterostilbene is a sirtuin-activating, better-absorbed stilbene studied for metabolic and lipid endpoints, frequently combined with nicotinamide riboside in human trials.

Effect summary

Studied health outcomes

Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
Health outcomeEffectMagnitudeGrade
LDL cholesterol↓DecreasesModerateB
Fasting blood glucose↓DecreasesMinorC
Cognitive function↑IncreasesMinorC
SIRT1 / longevity pathway activation↑IncreasesMinorC
Blood pressure↓DecreasesMinorC

Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data

Dosage guidance

How Pterostilbene is typically used

Typical dose
50–500 mg/day
Form
capsule
Timing
with meals

Pterostilbene is a methylated analogue of resveratrol with ~80% oral bioavailability vs ~1% for resveratrol. At higher doses (>250mg/day), some studies show LDL increases — monitor lipids. pTeroPure is a common branded form.

Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.

Evidence summary

What the research actually says

68Evidence confidence
Early / limited human trials8 randomized controlled trials · 2 meta-analyses / systematic reviews

Small human trials (often with NR); resveratrol-class mechanism

Pterostilbene is a sirtuin-activating, better-absorbed stilbene studied for metabolic and lipid endpoints, frequently combined with nicotinamide riboside in human trials.

20registered clinical trials reference this intervention
    3selected from 10+ PubMed papers (longevity / aging angle)
    Key active: Pterostilbene (methylated stilbene).

    According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.

    Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.

    Compare the evidence

    Related ingredients

    NMN (Nicotinamide Mononucleotide)β-烟酰胺单核苷酸
    79

    The headline NAD+ booster of the longevity world — human trials show it raises blood NAD+ and may support physical function.

    Nicotinamide Riboside (NR)
    79

    The leading NMN alternative — a direct NAD+ precursor with multiple RCTs confirming it safely raises NAD+ levels in humans.

    Nicotinamide (Niacinamide / B3)
    76

    The simplest and cheapest NAD+ precursor — with extensive human trial data in skin aging and DNA repair.

    Apigenin芹菜素
    70

    A flavone from parsley and chamomile that inhibits CD38 (NADase) — preserving NAD+ through a complementary mechanism to NMN or NR.

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