Evidence comparison

Spermidine vs Fisetin

How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.

Western · Polyamine · autophagy inducer

Spermidine

亚精胺

80Confidence

Human RCT evidence

RCTs: 43
Meta: 8
Trials: 21

Key active: Spermidine (natural polyamine)

Strong cross-species lifespan evidence; human trials emerging (autophagy, cognition)

Spermidine induces autophagy via hypusination of eIF5A and histone deacetylation, mimicking fasting. Landmark studies in yeast, flies, worms, mice and human cells link it to lifespan extension, cardioprotection and reduced age-related disease.

Full Spermidine evidence →

Western · Senolytic · flavonoid

Fisetin

漆黄素

66Confidence

Early / limited human trials

RCTs: 7
Meta: 12
Trials: 34

Key active: Fisetin (flavonoid senolytic)

Strong animal senolytic data; human trials early

Fisetin selectively clears senescent cells and extended lifespan and healthspan in aged mice; human senolytic trials are early-stage, making this promising-but-unproven.

Full Fisetin evidence →

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Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.