Evidence comparison
How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.
Western · NAD Precursor
Human RCT evidence
Key active: Nicotinamide riboside — direct NAD+ precursor
Multiple human RCTs on NAD+ elevation; larger aging trials ongoing
NR is phosphorylated by NRK kinases to NMN then to NAD+. Multiple Phase 1/2 RCTs confirm oral NR raises blood NAD+ 40–60% in older adults. Ongoing trials explore muscle, kidney, and metabolic aging.
Full Nicotinamide Riboside (NR) evidence →Western · Polyphenol
紫檀芪
Early / limited human trials
Key active: Pterostilbene (methylated stilbene)
Small human trials (often with NR); resveratrol-class mechanism
Pterostilbene is a sirtuin-activating, better-absorbed stilbene studied for metabolic and lipid endpoints, frequently combined with nicotinamide riboside in human trials.
Full Pterostilbene evidence →Need this for a decision?
We build evidence-graded comparisons for formulators, brands, clinics, and investors.
Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.