Origin & tradition
Not a traditional remedy: CoQ10 is an endogenous cofactor whose supplementation emerged from mitochondrial and cardiology research.
Western tradition · Mitochondrial cofactor
Coenzyme Q10 辅酶 Q10
The mitochondrial electron carrier that declines with age and statin use — with cardiovascular trial support.
256ClinicalTrials.gov matched
525PubMed RCT records
202Meta-analysis records
933+PubMed records
Coenzyme Q10Key active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Coenzyme Q10 (ubiquinone / ubiquinol).
CoQ10 is essential to the mitochondrial respiratory chain and acts as a lipid-phase antioxidant; the KiSel-10 trial linked CoQ10 plus selenium to reduced cardiovascular mortality in older adults.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Heart failure symptoms / ejection fraction | Increases | Strong | A |
| Fatigue | Decreases | Moderate | B |
| Blood pressure | Decreases | Minor | B |
| Statin-induced muscle pain | Decreases | Moderate | B |
| Sperm motility and quality | Increases | Moderate | B |
| Exercise performance | Increases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Coenzyme Q10 is typically used
- Typical dose
- 100–300 mg/day ubiquinol
- Form
- ubiquinol (active, reduced form) preferred over ubiquinone — especially over age 40
- Timing
- with a fat-containing meal for best absorption
Ubiquinol (QH) vs ubiquinone (CoQ10): ubiquinol is the reduced form, directly usable; ubiquinone must be converted by the body. Conversion declines with age. For statin-induced myopathy, 200–300mg/day is typically studied.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
76Evidence confidence
Extensive human-trial evidence525 randomized controlled trials · 202 meta-analyses / systematic reviews
Human RCTs (cardiovascular, statin myopathy); mitochondrial rationale
CoQ10 is essential to the mitochondrial respiratory chain and acts as a lipid-phase antioxidant; the KiSel-10 trial linked CoQ10 plus selenium to reduced cardiovascular mortality in older adults.
256registered clinical trials reference this intervention
3selected from 933+ PubMed papers (longevity / aging angle)
Key active: Coenzyme Q10 (ubiquinone / ubiquinol).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Coenzyme Q10 appears in
Compare the evidence
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Compare the evidence
How Coenzyme Q10 stacks up
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