Origin & tradition
Not traditional: GlyNAC is a research-driven combination targeting age-related glutathione decline.
Western tradition · Glutathione precursors
GlyNAC (Glycine + NAC) 甘氨酸 + N-乙酰半胱氨酸
A glutathione-restoring amino-acid pair with promising small trials on oxidative stress and aging markers.
12ClinicalTrials.gov matched
8PubMed RCT records
2Meta-analysis records
10+PubMed records
Glycine + N-acetylcysteineKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Glycine + N-acetylcysteine.
Glycine and N-acetylcysteine restore glutathione synthesis; small randomized and pilot trials in older adults report improved oxidative stress, mitochondrial function, strength, and cognition — promising but early.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Glutathione levels | Increases | Strong | B |
| Oxidative stress markers | Decreases | Strong | B |
| Mitochondrial function markers | Increases | Moderate | B |
| Muscle strength (elderly) | Increases | Moderate | C |
| Cognitive function (elderly) | Increases | Moderate | C |
| Biological age markers | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How GlyNAC (Glycine + NAC) is typically used
- Typical dose
- Glycine 2–3 g + NAC 1–2 g daily (combined as GlyNAC)
- Form
- powder or capsule (glycine + N-acetylcysteine taken together)
- Timing
- any time, with or without food
GlyNAC is a combination, not a single compound. Both precursors are needed for glutathione synthesis. Baylor College of Medicine trials (Dr. Sekhar) are the primary evidence base. Can be taken as separate supplements — no need for a branded product.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
71Evidence confidence
Early / limited human trials8 randomized controlled trials · 2 meta-analyses / systematic reviews
Small human RCT/pilot data; glutathione mechanism
Glycine and N-acetylcysteine restore glutathione synthesis; small randomized and pilot trials in older adults report improved oxidative stress, mitochondrial function, strength, and cognition — promising but early.
12registered clinical trials reference this intervention
3selected from 10+ PubMed papers (longevity / aging angle)
- Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
- Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
- GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging
Key active: Glycine + N-acetylcysteine.
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
GlyNAC (Glycine + NAC) appears in
Compare the evidence
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