Origin & tradition
Spermidine occurs naturally in wheat germ, natto, aged cheese and other fermented foods; its longevity link emerged from modern autophagy research rather than any single tradition.
Western tradition · Polyamine · autophagy inducer
Spermidine 亚精胺
A fasting-mimicking polyamine that triggers autophagy and extends lifespan across species.
24ClinicalTrials.gov matched
45PubMed RCT records
9Meta-analysis records
76+PubMed records
SpermidineKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Spermidine (natural polyamine).
Spermidine induces autophagy via hypusination of eIF5A and histone deacetylation, mimicking fasting. Landmark studies in yeast, flies, worms, mice and human cells link it to lifespan extension, cardioprotection and reduced age-related disease.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Autophagy markers | Increases | Moderate | B |
| Cardiovascular disease mortality (observational) | Decreases | Moderate | C |
| Cognitive decline / dementia risk | Decreases | Minor | C |
| Hair growth | Increases | Minor | C |
| Inflammation | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Spermidine is typically used
- Typical dose
- 1–2 mg/day (dietary equivalent) or 5–10 mg/day (supplement)
- Form
- capsule (wheat germ extract) or from diet (fermented foods, wheat germ, aged cheese)
- Timing
- with or without food
Dietary spermidine from natto, aged cheese, and wheat germ is likely equivalent to supplemental forms. 1 tsp of wheat germ (~3.5g) provides ~1 mg spermidine.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
80Evidence confidence
Human RCT evidence45 randomized controlled trials · 9 meta-analyses / systematic reviews
Strong cross-species lifespan evidence; human trials emerging (autophagy, cognition)
Spermidine induces autophagy via hypusination of eIF5A and histone deacetylation, mimicking fasting. Landmark studies in yeast, flies, worms, mice and human cells link it to lifespan extension, cardioprotection and reduced age-related disease.
24registered clinical trials reference this intervention
3selected from 76+ PubMed papers (longevity / aging angle)
Key active: Spermidine (C7H19N3) · ChEMBL CHEMBL19612 · max clinical phase 3 · natural product
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed, compound data from EMBL-EBI ChEMBL. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Spermidine appears in
Compare the evidence
How Spermidine stacks up
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