Origin & tradition
Green tea (Longjing, sencha, jasmine bases) has been a daily ritual beverage in China for over a millennium, valued for clarity, digestion, and vitality.
Eastern tradition · Premium Chinese Tea
Green Tea (EGCG) 绿茶 · 表没食子儿茶素没食子酸酯
The most-studied tea catechin, linked to lifespan and healthspan in models via AMPK, sirtuin and FOXO pathways.
281ClinicalTrials.gov matched
484PubMed RCT records
264Meta-analysis records
12+PubMed records
Epigallocatechin gallateKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: Epigallocatechin gallate (EGCG).
EGCG and ECG act as mitohormetic compounds: transient complex-I inhibition activates AMPK (AAK-2), SIRT1 (SIR-2.1), NRF2 (SKN-1) and FOXO (DAF-16), raising stress resistance and reducing fat content in model organisms.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| LDL cholesterol oxidation | Decreases | Moderate | B |
| Body fat / BMI | Decreases | Minor | B |
| Blood pressure | Decreases | Minor | B |
| Cognitive function | Increases | Minor | C |
| Antioxidant markers (ORAC) | Increases | Moderate | B |
| Fasting blood glucose | Decreases | Minor | C |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Green Tea (EGCG) is typically used
- Typical dose
- 400–800 mg EGCG/day
- Form
- standardized green tea extract (≥45% EGCG)
- Timing
- with meals — empty stomach increases nausea risk
3–4 cups brewed green tea provides ~200–400mg EGCG. Longjing and gyokuro have among the highest EGCG content. Avoid taking with milk (casein binds catechins).
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
88Evidence confidence
Extensive human-trial evidence484 randomized controlled trials · 264 meta-analyses / systematic reviews
Strong preclinical + human trials across cardiometabolic and cognitive endpoints
EGCG and ECG act as mitohormetic compounds: transient complex-I inhibition activates AMPK (AAK-2), SIRT1 (SIR-2.1), NRF2 (SKN-1) and FOXO (DAF-16), raising stress resistance and reducing fat content in model organisms.
281registered clinical trials reference this intervention
3selected from 12+ PubMed papers (longevity / aging angle)
Key active: Epigallocatechin gallate (C22H18O11) · ChEMBL CHEMBL297453 · max clinical phase 3 · natural product
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed, compound data from EMBL-EBI ChEMBL. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Green Tea (EGCG) appears in
Compare the evidence
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Compare the evidence
How Green Tea (EGCG) stacks up
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