Evidence comparison

Melatonin vs Magnesium

How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.

Western · Neurohormone

Melatonin

82Confidence

Extensive human-trial evidence

RCTs: 1,185
Meta: 661
Trials: 5

Key active: Melatonin (N-acetyl-5-methoxytryptamine — pineal neurohormone)

Extensive human RCTs on sleep; growing trial base for aging endpoints

Melatonin acts as a direct free-radical scavenger, mitochondrial membrane stabilizer, and circadian anchor. Its decline with age (~80% reduction) is considered a driver of circadian disruption and mitochondrial aging. Clinical trials cover sleep quality, cancer adjuvant, cardiovascular risk, and cognitive aging.

Full Melatonin evidence →

Western · Essential mineral

Magnesium

镁

77Confidence

Extensive human-trial evidence

RCTs: 2,984
Meta: 1,018
Trials: 2,045

Key active: Magnesium (glycinate, citrate, threonate)

Human trials (sleep, metabolic, BP); broad mechanistic role

Magnesium is a cofactor in ATP metabolism, DNA repair, and neuromuscular function; observational and trial data link adequacy to sleep quality, metabolic health, and lower inflammatory aging.

Full Magnesium evidence →

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Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.