Origin & tradition
Not traditional: marine omega-3s entered medicine through cardiovascular epidemiology and large randomized trials.
Western tradition · Essential fatty acids
Omega-3 (EPA/DHA) 欧米伽-3 脂肪酸
Among the most-trialed supplements in medicine, with emerging evidence on biological-age slowing.
1,985ClinicalTrials.gov matched
4602PubMed RCT records
1500Meta-analysis records
9+PubMed records
EPA & DHAKey active compound
Data definition. Matched records include all indexed medical endpoints for this intervention — not only longevity. Longevity-relevant records are screened separately and cited in the evidence summary below. Counts are matched-record volumes, not de-duplicated trials and not efficacy claims.
Why longevity buyers care
Key active: EPA & DHA (marine omega-3 fatty acids).
EPA and DHA modulate inflammation (resolvins), membrane function, and triglycerides; the DO-HEALTH trial reported small reductions in biological-aging markers and infections in older adults.
Effect summary
Studied health outcomes
Editorial summary — This table is curated by hand from published research consensus, not automatically calculated from our trial database. Grades reflect our interpretation of the literature. Treat as a starting point, not a definitive verdict. See the Evidence panel below for the underlying trial and paper counts sourced directly from ClinicalTrials.gov and PubMed.
| Health outcome | Effect | Magnitude | Grade |
|---|---|---|---|
| Triglycerides | Decreases | Strong | A |
| Cardiovascular events | Decreases | Moderate | B |
| Systemic inflammation (CRP) | Decreases | Moderate | B |
| Blood pressure | Decreases | Minor | B |
| Cognitive function / DHA levels | Increases | Moderate | B |
| Dry eye symptoms | Decreases | Moderate | B |
| Liver fat (NAFLD) | Decreases | Moderate | B |
Grade: A = robust RCTs · B = several RCTs / meta-analysis · C = limited or mixed RCTs · D = observational or early data
Dosage guidance
How Omega-3 (EPA/DHA) is typically used
- Typical dose
- 1,000–4,000 mg EPA+DHA/day
- Form
- triglyceride-form fish oil, krill oil, or algal oil (vegan)
- Timing
- with a fat-containing meal for absorption; split doses reduce fishy burps
Look for combined EPA+DHA total, not total fish oil weight. Prescription-strength omega-3 (Vascepa, Lovaza) used at 4g/day for triglyceride reduction. Algal oil is the direct DHA source for vegans.
Informational only — not a prescription or personalised medical advice. Consult a qualified clinician before starting any supplement or medication.
Evidence summary
What the research actually says
82Evidence confidence
Extensive human-trial evidence4,602 randomized controlled trials · 1,500 meta-analyses / systematic reviews
Very large human RCT base; aging markers emerging (DO-HEALTH)
EPA and DHA modulate inflammation (resolvins), membrane function, and triglycerides; the DO-HEALTH trial reported small reductions in biological-aging markers and infections in older adults.
1,985registered clinical trials reference this intervention
3selected from 9+ PubMed papers (longevity / aging angle)
- Systemic immune inflammation mediates the association of serum omega-3 and omega-6 polyunsaturated fatty acids with biological aging: a national population-based study
- Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation
- The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation
Key active: EPA & DHA (marine omega-3 fatty acids).
According to PubMed and ClinicalTrials.gov: trial counts from ClinicalTrials.gov, peer-reviewed literature from PubMed. Counts auto-refresh weekly; last checked 2026-07-19. They include trials across many endpoints, not only longevity.
Informational only — not medical advice, a treatment claim, or a substitute for a qualified clinician. Evidence strength varies; we show mixed and null results on purpose.
Evidence collections
Omega-3 (EPA/DHA) appears in
Compare the evidence
How Omega-3 (EPA/DHA) stacks up
Suppliers
No Omega-3 (EPA/DHA) suppliers listed yet
Tell us what you need and we will source suppliers for you.