Evidence comparison

Sulforaphane vs Curcumin (Turmeric)

How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.

Western · Phytochemical

Sulforaphane

80Confidence

Human RCT evidence

RCTs: 75
Meta: 25
Trials: 92

Key active: Sulforaphane (isothiocyanate from broccoli/broccoli sprout extract)

Strong preclinical + human RCTs in cancer and neuro; aging trials ongoing

Sulforaphane activates the NRF2-KEAP1 pathway, upregulating antioxidant response elements (HO-1, NQO1, GCLC). Human trials cover prostate cancer chemoprevention, autism (ABA-scale improvement), and schizophrenia. Preclinical evidence extends to senescence, neuroinflammation, and autophagy.

Full Sulforaphane evidence →

Eastern · Herbal Wellness

Curcumin (Turmeric)

姜黄素

80Confidence

Extensive human-trial evidence

RCTs: 513
Meta: 462
Trials: 388

Key active: Curcumin (diferuloylmethane)

Very large trial base for inflammation; longevity endpoints mechanistic; bioavailability-limited

Curcumin is a polyphenol acting on NF-κB-driven inflammation, autophagy and senescence pathways. The honest caveat: native curcumin has poor oral bioavailability, so formulation matters and many trials use enhanced forms.

Full Curcumin (Turmeric) evidence →

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Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.