Evidence comparison
How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.
Eastern · Functional Mushroom
猴头菇
Early / limited human trials
Key active: Hericenones & erinacines (botanical extract)
Small human cognition RCTs; NGF mechanism
Hericenones and erinacines can stimulate nerve growth factor (NGF) in models; small human trials suggest cognitive benefit in older adults and mild cognitive impairment.
Full Lion's Mane evidence →Eastern · Adaptogen Herb
印度人参
Human RCT evidence
Key active: Withanolides (botanical extract — KSM-66 / Sensoril standardized)
Multiple high-quality RCTs (stress, hormones, cognition, muscle); strong evidence base
KSM-66 and Sensoril extracts show consistent HPA-axis regulation in human RCTs: reduced cortisol, improved testosterone, muscle strength, and cognitive performance. Animal studies show healthspan extension and Nrf2/FOXO pathway activation. The withanolide withanone inhibits CDK4/6 and may suppress cellular senescence.
Full Ashwagandha (KSM-66) evidence →Need this for a decision?
We build evidence-graded comparisons for formulators, brands, clinics, and investors.
Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.