Evidence comparison
How they actually compare on the evidence — trial volume, literature, mechanism, and our honest confidence grade. Higher counts reflect research attention, not proof of superiority.
Western · Muscle & brain energy
肌酸
Extensive human-trial evidence
Key active: Creatine monohydrate
Strong human RCTs (muscle/sarcopenia); growing cognitive data
Creatine buffers cellular ATP; combined with resistance training it counters sarcopenia in older adults, and trials are exploring cognitive and mood benefits under metabolic stress.
Full Creatine evidence →Western · Amino Acid
Extensive human-trial evidence
Key active: Glycine (conditionally essential amino acid)
Strong NIH preclinical lifespan data; GlyNAC human RCT; direct aging trials limited
Glycine is rate-limiting for glutathione synthesis alongside cysteine, and is required for collagen and creatine biosynthesis. It also suppresses mTORC1 via its sensor GCN2. Glycine supplementation extended median lifespan in mice by 28–31% (NIH ITP). The GlyNAC combination (2021 Baylor RCT) corrected multiple aging hallmarks in older adults.
Full Glycine evidence →Need this for a decision?
We build evidence-graded comparisons for formulators, brands, clinics, and investors.
Informational only — not medical advice or a recommendation to take either. Trial and literature counts are registry/database matches and include endpoints beyond longevity. See each ingredient page for sources.